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We are looking for an experienced cell biologist to participate in our exciting studies of the human protein kinome. This Lead / Senior Scientist position is part of the Blue Sky Initiative Seeing the Invisible in Protein Kinases at St. Jude Childrens Research Hospital in Memphis TN.

As a member of the Cell-Based Assays team the candidate will use their molecular biology biochemistry and cell culture skills to perform research that translates novel insights regarding kinase structure and regulation in vitro into functional effects in cells. Additionally the candidate will assist in performing cell-based analysis in high- medium- and low-throughput platforms of candidate inhibitors of kinases. The work is diverse providing an opportunity to study multiple kinases perform appropriate background research optimize cell-based assays of various types using many different cell lines or primary cells. Not only are the cell-based studies used to validate the structural findings but they are also used to discover new kinase-mediated biology or new mechanisms of kinase regulation.

The Blue Sky Initiative Seeing the Invisible in Protein Kinases is an inter-disciplinary project in the Department of Structural Biology and is supported by US $50 million in institutional funding. This large-scale project leverages ultra-high field nuclear magnetic resonance (NMR) complemented with cryoEM X-ray crystallography data-science and computational approaches to characterize the conformational landscape of the human kinome. Knowledge of the conformations of kinases is then used to discover new biology regarding kinase function and regulation in cells understand the structural and functional consequences of disease-associated mutations and identify novel therapeutic opportunities.

Responsibilities :

• Research kinase-mediated signaling pathways kinase targets or kinase-dependent phosphorylation events and cellular outcomes of such pathways for assigned kinase projects.
• Identify appropriate cellular assays and cells to perform structure-guided analysis of kinase signaling output and cellular phenotypes related to structure-guided perturbations in kinase regulation or function.
• Develop strategies and plans for implementing cell-based assays including but not limited to evaluation of protein phosphorylation protein interaction protein localization RNA abundance (qRT-PCR) protein ubiquitination and protein abundance.
• Develop strategies and plans for implementing cell-based phenotypic assays including but not limited to viability apoptosis autophagy migration or differentiation.
• Perform optimization and troubleshooting of cell-based assays.
• Perform statistical analysis using graphing software or R scripts.
• Interpret analyze and communicate cell-based assay results within the Cell-Based Assays team and with collaborators on specific kinase projects.

Experience and Expertise :

Technical Capabilities :

Competencies :

Minimum Education and Experience for either level :

Minimum Experience for Senior Scientist :

Minimum Experience for Lead Scientist :

A reasonable estimate of the current salary range is $104000 - $186160 per year for the role of Senior Scientist $125840 - $238160 per year for the role of Lead Scientist.

The Worlds Brightest Minds Always Innovate

At St. Jude Childrens Research Hospital we know what can be achieved when the brightest scientific minds face the fewest barriers. Thats why we provide

You will see firsthand how your science translates into survival for the children that we serve. Quite simply at St. Jude we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.

Better at Work. Better at Life.

When you work at St. Jude youll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and youll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a Best Place to Work.

Have More in Memphis

Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can Have More in Memphis .

Compensation

In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125840 - $238160 per year for the role of Cell Assay Lead / Senior Scientist - Blue Sky Kinases.

Explore our exceptional benefits!

St. Jude is an Equal Opportunity Employer

No Search Firms

St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and / or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Required Experience :

Senior IC

Key Skills

Laboratory Experience,Mammalian Cell Culture,Biochemistry,Assays,Protein Purification,Research Experience,Next Generation Sequencing,Research & Development,cGMP,Cell Culture,Molecular Biology,Flow Cytometry

Employment Type : Full-Time

Experience : years

Vacancy : 1

Yearly Salary Salary : 125840 - 238160